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Therefore, ID impairs PHD activity, leading to the accumulation of HIF-1 (109)

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10.1253/circj.cj-08-1041 275 TakeuchiH.ThongborisuteJ.MatsuiY.SugiharaH.YamamotoH.KawashimaY

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If slow titration does not work to minimize side effects, suggest small food portions and make sure any reflux symptoms are appropriately treated (a short course of a proton pump inhibitor is most commonly recommended) (Gorgojo-Martnez JJ et al, J Clin Med 2022;12(1):145)

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