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The incidences of major depressive disorder, anxiety, and suicidal ideations or attempts, as well as their hazard ratios, are higher in the GLP-1 RA group, indicating an association with GLP-1 RA treatment over time

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"These findings may inform shared decision making when considering GLP- 1 receptor agonist therapy and highlight the need for further evaluation of dermatological outcomes in future studies." The study involved a large number of people: 12,004 patients using GLP-1 drugs were compared to 15,221 using SGLT-2 inhibitors, with an additional 11,964 GLP-1 users compared to 11,233 using DPP-4 inhibitors

So when that system changes, the experience changes

Critics of GLP-1 therapies often portray those who use these medications as opting for an easy way out to achieve thinness, perpetuating longstanding biases like those historically associated with bariatric surgery (Heitmann, 2025)

Lombard et al., 1989