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However, the powerful catalytic properties of PROTACs could potentially narrow their therapeutic window and their low selectivity for tumours would cause severe systemic toxicity owing to the so-called on-target effect 6

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S., Grusdat, M., Schlicker, L., Hunewald, O., Dostert, C., Merz, M

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Methotrexate, vincristine, PEG-asparaginase and prednisone (MOAP) for patients (pts) with refractory or relapsed acute lymphoblastic leukemia (ALL)