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In response to oxidants, cysteine modification on Keap1 releases NE2FL2, which is then stabilized and transported to the nucleus where it activates transcription of antioxidant genes, including proteasomal PA28
It leverages endogenous pathways that deliver essential macromolecules such as transferrin and insulin into the brain
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10.1016/j.celrep.2014.03.048 15 ChiZ.ZhangJ.TokunagaA.HarrazM
The subjects reported decreased vigor and increased fatigue symptoms that mirror clinical hypogonadism
JAMA (2016) 315(8):80110.10.1001/jama.2016.0287 17 YukiKMurakamiN
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