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In terms of duration of action, exenatide and lixisenatide are considered short-acting GLP-1 receptor agonists with a half-life of approximately 25 h, while dulaglutide, liraglutide and exenatide-LAR are considered long-acting GLP-1 receptor agonists with a half-life of 12 hseveral days

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Effects of glucagon-like peptide-1 receptor agonists on cardiovascular and renal outcomes: A meta-analysis and meta-regression analysis

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We have therefore identified a specific group of nerve cells that is necessary for the effects that semaglutide has on weight and appetite, but which does not appear to contribute to any significant extent to side effects such as nausea. Separating benefits from side effects One reason this discovery is so important is because it could help drug developers design more precise treatments