To generate mice with inducible deletion of IGF1R in MSCs, we crossed Nestin-Cre ER transgenic mice with Igf1r fl/fl mice
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Ferroptosis contributes to follicular depletion, ultimately leading to DOR (Figure 4B)
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According to emerging studies, resolution biology specialized lipid mediators (resolvins, protectins, maresins), Treg-derived cytokines, and vagus-nerve-dependent anti-inflammatory pathways that actively terminate harmful immune activity has a major effect on neuroprotection in PD