Long-term Persistence of Hormonal Adaptations to Weight Loss New England Journal of Medicine 365(17) 2011PMID: 22011582 NEJM 8 Leibel RL, Rosenbaum M, Hirsch J Changes in Energy Expenditure Resulting from Altered Body Weight New England Journal of Medicine 332(10) 1995PMID: 7632212 PubMed 9 Mller MJ, Geisler C, Heymsfield SB, Bosy-Westphal A Recent Advances in Understanding Body Weight Homeostasis in Humans F1000Research 7 2018PMID: 30090625 PubMed 10 Anderson JW, Konz EC, Frederich RC, Wood CL Long-term Weight-Loss Maintenance: A Meta-Analysis of US Studies American Journal of Clinical Nutrition 74(5) 2001PMID: 11684524 PubMed References open in a new tab
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Herein, we review the existing evidence and illustrate the neuroprotective pathways that are induced following GLP-1R activation in neurons, microglia and astrocytes