The broader receptor profile of these newer-generation GLP-1 receptor agonists is thought to offer clinical advantages, potentially providing better tolerability or enhanced effectiveness due to simultaneous modulation of reward-related neural circuits and metabolic pathways (Ray 2023
Rather, it means that the mechanism has not been reduced to a simple receptor-to-pathway model
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GLP-1 analog modulates appetite, taste preference, gut hormones, and regional body fat Stores in Adults with obesity
Wacker M, Holick MF