APR-246/MQ has also been shown to inhibit thioredoxin reductase (TrxR) in vitro and in living cells 15
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To create the glutathione model used in this paper, we took the model from [11] and added the glutathione pathway, homocysteine, cystathionine, cysteine, glutamylcysteine, GSH, and GSSG [Figure 1] from a previous model of glutathione metabolism [14]
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Lesch KP, Widerlv E, Ekman R, Laux G, Schulte HM, Pfller H, Beckmann H
Declining glutathione levels have been found in patients with Alzheimers, Parkinsons, and other neurodegenerative conditions