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Magnone, M

GLP-1 can induce the expression of FNDC5 in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of WAT to BAT and enhancing energy metabolism [85]

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Trials and post-market surveillance identified risks in specific populations, such as those with a history of medullary thyroid cancer, pancreatitis, or severe kidney disease, and screening for those risks is not possible in an over-the-counter setting

Before starting treatment with tirzepatide for weight reduction, tell your doctor if you have a personal or family history of thyroid cancer or multiple endocrine neoplasia syndrome (MEN syndrome)

Mounjaro helps control appetite