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I don't get the stigma of saying people with PCOS shouldn't use it 'cause it's off-label

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Highly specific epigenome editing by CRISPRCas9 repressors for silencing of distal regulatory elements

Quite remarkably, in those with low POP levels, the typically robust association between diabetes and obesity was not observed in a nested case-controlled study, suggesting that obesity may exaggerate the metabolic disturbances caused by POPs (perhaps because adipose tissue provides a reservoir for fat-soluble toxins), rather than being directly responsible for the altered metabolism

Larger randomized trials are clearly needed to define the role of herbal supplements in the management of male infertility.

(PubMed) Harbige LS