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In a 48-week trial of adults with obesity (but without type 2 diabetes), participants taking the highest dose (12 mg weekly) lost an average of 24.2% of their body weight

In contrast, obesity reduces the expression of KLB in subcutaneous and visceral adipose tissue ( As an endocrine factor, FGF21 has been shown in preclinical models to exert effects in diverse tissues beyond liver, including adipose tissue, pancreas, skeletal muscle, and the central nervous system

Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight

Taking the time to verify your benefits and work with your doctor to document medical necessity can make a big difference in getting the support you need for your health journey

While its similar to other GLP-1s like Ozempic (semaglutide) and Trulicity (dulaglutide), Mounjaro mimics a second hormone along with the glucagon-like peptide-1 (GLP-1): GIP, which stands for glucose-dependent insulinotropic polypeptide

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