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However, our study focuses specifically on pharmacological aspects of GLP-1R agonism, with prolonged incubations deliberately chosen to mimic in vivo drug exposure, and knockdown of both -arrestin isoforms to better approximate the response to exendin-phe1 and related agonists

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Rolland et al, 1995)

Such a mechanism could theoretical be mediated by the oncoprotein MDM2, which interacts with p53 but has recently also been found to associate with certain cell surface receptors and regulate their functions (Shenoy et al, 2001)

Gastrointestinal adverse events: The most common adverse effect is gastrointestinal adverse events

doi: 10.3390/life11010056 35 Baia-SilvaDCMonteiroWMde LacerdaMVGSecundinoNFCPimentaPFP