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They stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is released only when blood glucose levels are elevated
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How Long-Term GLP-1 Therapy Prevents Weight Regain Rather than viewing semaglutide as a short-term intervention, medical evidence increasingly supports chronic weight managementmuch like treating high blood pressure or diabetes with ongoing medication
In the action in diabetes and vascular disease (ADVANCE) trial, a study involving 11,140 subjects with T2DM who were followed for a median duration of 4.4 years, a higher HR was associated with a significantly increased risk of all-cause mortality, cardiovascular death, and major cardiovascular events (death, nonfatal acute myocardial infarction [AMI] or nonfatal stroke) [39]
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