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Metabolic effects through IGF-1 receptor pathways

(6) Inadequate levels of B12 can disrupt this cycle and lead to the accumulation of homocysteine, which is toxic to neurons and poses an increased risk factor for cardiovascular disease, stroke, and cognitive decline

So, injection is an extremely good treatment, but how often can you get a B12 shot, lets find out

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Yin Y, Li S, Liao W, Lu Q, Wen X, Lu C (2010) Photosystem II photochemistry, photoinhibition and the xanthophyll cycle in heat-stressed rice leaves