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The approval was based on results from Phase 3 clinical trials that evaluated tirzepatide in adults with obesity and moderate-to-severe OSA
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Several other studies have also provided evidence that GLP-1RA can reduce hepatic fat accumulation and reduce steatosis in liver tissue by regulating the expression of genes and proteins related to the fat synthesis pathway [109,110]
Mutations in the SNCA gene promote -syn aggregation into oligomers or fibrils, which disrupt the ubiquitin-proteasome system and impair membrane binding by reducing its N-terminal -helical structure, leading to compromised membrane integrity and increased permeability (141, 142)
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