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Despite reasonably successful progress in clinical trials of its most advanced oral candidate danuglipron, the company halted development in April, owing to a possible drug-induced liver injury in one participant of an earlier study

Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)

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If so, the two types of heart failure may be very similar, except that the cause of heart failure with a preserved ejection fraction may not be the same as that with a reduced ejection fraction

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