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For context, NICE guidance on existing approved GLP-1 receptor agonists for example, NICE TA875 (Semaglutide for managing overweight and obesity, 2023) acknowledges GI side effects as a recognised class effect and supports gradual dose escalation to improve tolerability

Measures Exposure Exposure was defined based on GLP-1 medication usage, as determined by medication order records for prescriptions and refills in the EHR

To use fat for energy it requires oxygen, so this makes sense

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