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Shine B, McKnight RF, Leaver L, Geddes JR

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GLP-1RAs exert their anti-obesity effects primarily by amplifying signaling within this gutbrain axis, delivering a sustained satiety signal that overrides endogenous regulatory constraints ( Physiological GLP-1 does not function as a classical circulating hormone

They induce the expression of inflammation-related genes, including CCL2 and CCL7, which enhance macrophage recruitment and chemotaxis ( 7 Ferroptosiss bidirectional relationship with macrophage function 7.1 Iron homeostasis controls macrophage polarization Iron metabolism is quite crucial for macrophage phenotypic differentiation

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