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This reduction is often caused by oncogenic mutations in metabolic enzymes like succinate dehydrogenase (SDH), fumarase (FH), and isocitrate dehydrogenase (IDH1/2), leading to the accumulation of metabolites such as fumarate, succinate, and 2-hydroxyglutarate (2HG), respectively (reviewed in refs

Initially developed for diabetes, they are now widely used for obesity treatment and are under investigation for a wide range of other conditions, from kidney and heart disease to addiction to dementia

However, more people reported higher rates of side effects while on orforglipron compared to Rybelsus, which caused them to stop taking the pill

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Adrenalectomy blocked it

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