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It is well established that the interaction of GRXs with glutathione adducts in the so called scaffold site is important for oxidoreductase activity 13,14,15

Arthur JS, Ley SC

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Micromachines 12(11):1324 Tang H et al (2018) In vivo targeted, responsive, and synergistic cancer nanotheranostics by magnetic resonance imaging-guided synergistic high-intensity focused ultrasound ablation and chemotherapy

The first Phase 3 results (TRIUMPH-4) were just released in December 2025

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