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Contrave : Contrave is a combo of two medications that work on the brains hunger and reward system
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In the head-to-head SURPASS-2 trial, tirzepatide 15mg led to 5.5 kg more weight loss than semaglutide 1mg
It's worth noting that no head-to-head randomized controlled trials have directly compared tirzepatide to other obesity medications like semaglutide 2.4 mg in the obesity setting
Canada added the cardiovascular label in 2024, and provincial formularies followed by mid-2025, expanding patient eligibility
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