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STEP 1 Trial - New England Journal of Medicine : The landmark clinical trial demonstrating 14.9% average weight loss with semaglutide 2.4mg over 68 weeks, establishing the efficacy and safety profile for weight management
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You must also meet BMI requirements (30 or 27 with weight-related comorbidities) and pass medical screening for contraindications
Thyroid tumors or cancer: Though seen only in animal studies, symptoms like neck swelling, hoarseness, or difficulty swallowing should be evaluated immediately
Going forward, the increased focus on preventive care, rise in obesity rates, growing awareness of cardiovascular and weight-loss benefits and expansion of insurance coverage for obesity treatments will drive the growth
NAE signals were considered significant if 3 reports existed and the lower limit of 95% CI of the ROR exceeded 1 28
