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Following reperfusion, platelet and leukocyte adhesion and aggregation form microthrombi, triggering the no-flow phenomenon, which blocks blood flow reperfusion and the delivery of repair factors, exacerbating tissue hypoxia and inflammatory responses

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Results GSDMD-mediated pyroptosis is activated in ischemic hindlimbs To investigate the involvement of GSDMD-mediated pyroptosis in hindlimb ischemic injury in vivo, we established hindlimb ischemia (HLI) model by ligation of the femoral artery in wild-type (WT) mice

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