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Because of the low toxicity of vitamin B 12 , no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board (21)
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Many people are also genetically predisposed to having impaired B12 absorption
In contrast, oral vitamin B12 supplements need to pass through your stomach acid and digestive system, and their absorption can be less reliable, especially if there are absorption issues
Self-prescribing high-dose B12 without medical indication is inadvisable, particularly for individuals with underlying health conditions
Acta Orthop Scand 71:316321 Ethics declarations Conflict of interest The authors declare that they have no conflict of interest
