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Because the autonomic nervous system regulates digestive motility, POTS patients frequently swing between extremes: rapid gastric emptying (causing diarrhea and malabsorption) or delayed gastric emptying (gastroparesis, causing severe nausea and early satiety)

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All of those factors help slow kidney disease progression, so I think GLP-1 receptor agonists are a great addition to our existing armamentarium. Where Obesity, CKD, and T2D Intersect with Semaglutide: The FLOW Trial The approval for semaglutide for patients with T2D and CKD was based on data from FLOW, a phase 3b, multinational, parallel-group, double-blind, randomized, placebo-controlled trial investigating the effects of 1.0 mg once weekly semaglutide, a once-weekly GLP-1RA, on kidney outcomes in participants with CKD and T2D

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