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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

In tendon fibroblasts, BPC-157 has been reported to increase expression of growth hormone receptor at mRNA and protein levels, potentially priming cells to respond to growth hormone via downstream Janus kinase (JAK) signaling

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Zom RL 1 , van Baal J, Goselink RM, Bakker JA, de Veth MJ, van Vuuren AM