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Several real-world studies based on administrative data and pharmacy reports have demonstrated that reduced adherence to antidiabetic therapy is associated not only with poorer glycemic control but also with a significant increase in overall mortality and hospitalizations for all causes [70, 71]

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GSH system and ferroptosis in the myocardium Ferroptosis Ferroptosis is a novel form of programmed cell death characterized by the accumulation of iron-catalyzed lipid peroxidation

The combination may result in additive or synergistic gastrointestinal distress, potentially severe enough to cause dehydration, electrolyte disturbances, or medication non-adherence