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Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH
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TNF- induces insulin resistance via inhibiting IRS-1 and GLUT4 expression in adipocytes
Jun 2018;112:12-17
Self-medication is not advisable
Liraglutide (Saxenda) Saxenda received FDA approval on December 23, 2014 as the first GLP 1 receptor agonist specifically indicated for chronic weight management
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