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Subjects were randomized (6:1) to subcutaneous self-injections of once-weekly cagrilintide, once-daily liraglutide, or volume-matched placebo

The robust triglyceride reduction seen at higher retatrutide doses is attributed to the glucagon receptor pathways direct stimulation of hepatic fat oxidation, which reduces hepatic VLDL secretion and subsequently lowers circulating triglyceride concentrations

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Gradual Dosage Increase

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