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For other parenteral routes such as subcutaneous and intramuscular injections, the bioavailability may still be close to 100 % for most therapeutic drugs (F = 0.751), since little or no significant metabolism of the drug occurs in the skin or muscle and these small molecules (MW 0 min) compared to the intravenous route

doi: 10.1212/01.wnl.0000187889.17253.b1 51 MenonP

Persistently high levels are more commonly linked to supplements or medical conditions

PubMed PMID: 6726473