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Trimethylamine n-oxide supplementation abolishes the cardioprotective effects of voluntary exercise in mice fed a Western diet

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Testing may include SAM, SAH, the SAM-to-SAH ratio, methionine, homocysteine, copper, ceruloplasmin, zinc, CBC, comprehensive metabolic panel, kidney function, liver markers and exposure-specific testing when appropriate

About 20% of patients taking the higher dose in both trials experienced this effect, compared with about 5% of those on the lower dose

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