glp-1 physiology informs the pharmacotherapy of obesity Frontiers The evolving landscape of obesity

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However, GLP1R agonists produce a variety of effects in the brain as well, making efforts to increase the ability of such drugs to cross the blood-brain barrier of high interest

doi: 10.2337/dci18-0007 2 VaidyaVGanganNSheehanJ

The Food and Drug Administration granted expedited approval to orforglipron, a GLP-1 drug that works like widely used injectable medications to mimic a natural hormone that controls appetite and feelings of fullness

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40 Indeed, patients at later stages of HF may respond differently to therapy that improves outcomes in less severe disease states