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doi: 10.1016/S2213-8587(14)70169-X 63 SimeoliCFerrignoRDe MartinoMCIacuanielloDPapaFAngellottiDet al
Several CVOTs have demonstrated that GLP-1 RAs reduced CV risk in T2DM patients with established ASCVD or high CV risk independent of HbA1c levels
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Standard research protocol structure: Loading phase (week 1) : 300mcg daily, initiated 35 days post-injury or surgical repair Active phase (weeks 26) : 300mcg daily, continued through hard callus formation Taper phase (optional, weeks 78) : 150mcg daily or every other day if extending beyond six weeks Daily administration maintains more stable plasma levels than alternate-day or pulsed protocols
Heller, R
Research has examined multiple administration routes with varying levels of success
