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There are no large controlled human trials establishing combined efficacy or safety, and the pairing remains a subject of ongoing preclinical interest rather than clinical fact

The first nootropic to use the term was a drug developed in the 1960s called piracetam.60 61 It was intended to treat anxiety and provide patients with a soothing experience that might even lull them to sleep.2 The effect was quite different than what its creators intended, as users reported sharper focus, and later testing pointed toward improved memory

The amount of water added to the vial determines the concentration, and the concentration determines everything else

Xue et al., 2004a

Start with 0.5-1mg daily if injecting, or a 1-2% topical product applied once daily