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doi:10.1017/s1463423619000227 Alpert JS

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Wegovy must be used for the following FDA-approved indications to get Aetna coverage: Use the medication along with a reduced-calorie diet and increased physical activity: To lower the risk of serious cardiovascular events (such as death from cardiovascular disease, non-fatal heart attack, or non-fatal stroke) in adults who have existing heart disease and are either overweight or obese

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Guidance on strategies to minimize GI adverse events in women is largely empirical