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The replacement of Trp by d-Trp in position 3 further increased the potency of inhibitory peptides

(Frontiers in Pharmacology, 2022) reported pharmacokinetics and tissue distribution in rats and dogs, including a rapid plasma half-life under 30 minutes after IM or IV dosing

Because it has a C12 (lauric acid) fatty acid chain, this ingredient can potentially feed the Malassezia yeast that causes fungal acne

Furthermore, in vitro treatment of human bronchial epithelial cells with P.bivia supernatant altered lipid profiles, promoting pro-inflammatory metabolites and suppressing anti-inflammatory lipids, thereby elucidating how microbial metabolites drive inflammatory responses in asthma (Yan et al., 2024)

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Microscopically, the treated animals retained more axons and showed less white matter damage