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[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility

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Another study reported that SDH activity increases ROS accumulation and promotes lipid peroxidation, thereby facilitating ferroptotic cell death 113

Primary Compound: delta sleep-inducing peptide , or simply dsip delta sleep inducing peptide