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Current data suggests that dopamine metabolism, low glutathione (GSH) and high levels of iron and calcium contribute to ROS accumulation in dopaminergic neurons (Dias et al., 2013)
The index date for the case group was defined as the date of the first tirzepatide prescription, while for the control group, it was the date of the first prescription for one of the aforementioned anti-obesity medications
The nasal spray format was not chosen for convenience, but for its utility in modeling alternative delivery pathways - especially in metabolic or neuroendocrine research scenarios
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According to the same poll, 40% of users say they took them primarily for weight loss, while 60% were using GLP-1s to treat a chronic condition including diabetes or heart disease
Kalkan KT et al
