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The pivotal early-efficacy readout in obesity came from a randomized, double-blind, placebo-controlled, dose-finding Phase 2 trial published in The Lancet Diabetes & Endocrinology (le Roux and colleagues), conducted across 43 centers in 12 countries and registered as NCT04667377
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Cagrilintide + retatrutide swaps semaglutide for retatrutide, which already hits three receptors (GLP-1, GIP, glucagon)
None of the patients in this study achieved live births in their previous cycles
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