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Ann Neurol 2005
Melanin is the prominent reason behind the darkening of the skin
This system releases ethyl caffeate (EC) and 4-hydroxybenzyl alcohol (HBA) in response to ROS at the IRI site, synergistically scavenging ROS, alleviating mitochondrial oxidative damage, restoring energy metabolism, inhibiting apoptosis and inflammatory responses, and significantly improving renal function and structural integrity [67]
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