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B12 is one essential piece in that picture
The first retinoids were used in skincare as an acne treatment in the 1970s, but patients soon began enjoying other positive side effects, like the reduction of wrinkles and hyperpigmentation
For example, women with Hashimoto's thyroiditis receiving selenium reported better emotional regulation and cognitive clarity in addition to biochemical changes (198)
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Real-world biology is rarely that tidy
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