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We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion

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Targeted metabolomics using LCMS/MS The AbsoluteIDQ p180 kit (Biocrates) with a liquid chromotographytandem mass spectrometry (LCMS/MS) system (Sciex 6500 + QTRAP) was used to quantify metabolites in aged pancreatic islet cells

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