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For example, if a phase I metabolite cant be cleared out quickly enough with phase II conjugation, then it can cause oxidative stress

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The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration

The most common is hypothyroidism