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Although GLP-1 receptor agonists often lead to a decrease in fat mass and lean body mass during weight loss, recent clinical trials have confirmed that this does not necessarily have a negative impact on functional capacity

Specifically, researchers looked at the rate of discontinuation of the drugs due to adverse events compared to placebo groups and found higher rates of nausea, vomiting and diarrhea

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Ikonomidis I, Pavlidis G, Thymis J, Birba D, Kalogeris A, Kousathana F, Kountouri A, Balampanis K, Parissis J, Andreadou I, Katogiannis K, Dimitriadis G, Bamias A, Iliodromitis E, Lambadiari V

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Medications affecting oxidative stress and inflammation Cell stress and apoptosis Oxidative stress and activation of the unfolded protein response are two well-recognized cell stress pathways that cause cell death in MASH