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The slow digestion/ delayed stomach emptying may cause a range of digestive symptoms, including: Bloating Nausea Feeling overly full or sluggish after meals Indigestion or discomfort These issues can make it harder for some patients to enjoy their meals or feel comfortable after eating
Another AD study, focused on targeting CD38, showed that CD38 knockdown in APP Swe mutation-expressing transgenic mice enhanced NAD + levels and reduced A plaques in brain extracts, mirrored by some improvement of cognitive performance 270,274
13, 20, 26, 27, 48, 70, 71, 72 They are actively taken up into the brain 73 and can affect diverse physiological processes such as cell signaling, 71 neurotransmitter synthesis and release, 70 mitochondrial function, 20 lipid metabolism, 13, 74 immune function, 75 cellcell interactions 76 and gene expression
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