Possible complications related to GLP-1 use under anesthesia include: Aspiration due to delayed gastric emptying Hemodynamic instability: pronounced hypotension or bradycardia Altered response to opioids and sedatives, requiring dose changes Perioperative hypoglycemia from additive glucose-lowering effects Nausea and vomiting increasing postoperative airway risk Delayed recovery of bowel function, affecting discharge timing Interference with regional anesthesia sympathetic block assessment Post-Surgery Restart Post-surgery restart of GLP-1 receptor agonists should be done with clear criteria and close coordination to avoid complications and maintain therapeutic goals
Furthermore, the combined use of (-)-Vestitol and Salviolone introduces the possibility of interactions beyond the observed synergistic effects for AD
Even though these otoprotective agents represent a promising new therapeutic strategy for ameliorating, delaying, or even preventing the impact of noise on hearing, finding the ideal therapeutic agent will remain a challenging topic for the future
doi: 10.1016/J.ECLINM.2024.102661 49 BettgeKKahleMAbd El AzizMSMeierJJNauckMA
10.1038/s41380-020-00901-5 23
Innovations in drug delivery such as once-weekly formulations and auto-injectors are contributing to the market demand