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These alterations often coincide with, or precede, early cartilage injury, diminish the shock absorbing capacity of the subchondral plate, and accelerate degeneration of the overlying cartilage (Bolbos et al., 2008

doi: 10.1186/s12937-024-00934-4 65

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Metabolites of omega-3 PUFAs are vital for the synthesis of several inflammatory mediators including prostaglandins (PG), leukotrienes (LT), thromboxanes (TX), protectins , and resolvins 709

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Scheithauer TPM, Rampanelli E, Nieuwdorp M, Vallance BA, Verchere CB, van Raalte DH, et al