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This is seen when the plasmatic levels are above 5060 pM, equivalent to more than five times the levels seen post-prandial in healthy individuals challenged with a bolus of glucose, or 10-fold their basal levels (153, 216), adding further doubt to the physiological hormonal dogma of intestinal GLP-1

Preclinical studies have identified GLP-1 receptors throughout the gastrointestinal tract, including on enteroendocrine cells, neurons, and immune cells

The therapeutic agent liraglutide alleviates ferroptosis by attenuating lipid peroxidation, thereby mitigating its detrimental effects on hippocampal neurons and synaptic plasticity, and ultimately delaying the onset and progression of DACD (Figure 3)

Images were captured usinga light microscope and analyzed using Image-Pro Plus 6.0 software (Media Cybernetics

Dietary polyphenols and human gut microbiota: a review