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Theyre all over the news and social media right nowbut what do they actually do
No human clinical trials of 5-Amino-1MQ in obesity, sarcopenia, or any other indication have been published in peer-reviewed journals
Conflict of interest The authors have no conflict of interests related to this publication
Neuropharmacology 62 , 19161927 (2012)
By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes
Owing to this large age gap, the beneficial effect of dexamethasone may have been partly masked in the older adult cohort
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